Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 11;12(1):26–40. doi: 10.1089/brain.2020.0935

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© Hannah Clarke et al. 2022; Published by Mary Ann Liebert, Inc.

This Open Access article is distributed under the terms of the Creative Commons License [CC-BY] (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

FIG. 4. — Nodes identified as hubs, change dependent on risk factor profile. This figure shows the changes in nodes defined as hub regions, when you transition from a low-risk group to a high-risk group. A size scale is used to define hub changes, large symbols indicate gained hubs whereas small symbols represent those hubs which are lost. The intermediate size indicates hubs that remain. (A) Comparing individuals without an FH with those with a positive FH indicates that two hubs remain unchanged, whereas three are gained and three are lost. (B) Comparing APOE4 noncarriers with carriers results in a gain of three hubs, loss of two hubs, but leaves two hubs unchanged. (C) In comparison with healthy individuals, obese participants gained two hubs, lost two hubs, and two hubs remain APOE4, apolipoprotein-E ɛ4; FH, family history of dementia.