6-AN |
6-aminonicotinamide |
2-DG |
2-Deoxy-D-glucose |
2-D-HG |
2-D-hydroxyglutarate |
α-KG |
α-ketoglutarate |
AAs |
Amino acids |
ABT-199 |
Venetoclax |
ABC |
ATP-Binding Cassette |
Akt |
Protein kinase B |
ALAT |
Alanine transferase |
AML |
Acute myeloid leukaemia |
AMPK |
AMP-activated protein kinase |
Bap |
A combination of lipid-regulating bezafibrate (BEZ) and the sex hormone medroxyprogesterone acetate |
BCAT1 |
branched-chain amino acid transaminase 1 |
BMME |
Bone marrow microenvironment |
Cas9 |
CRISPR-associated protein 9 |
CD |
Cluster of differentiation |
c-KIT |
Cluster of differentiation 117 |
CKMT1 |
Creatine kinase mitochondrial 1 |
ClpP |
ATP-dependent Clp protease |
CoA |
Coenzyme A |
CPT1A |
Carnitine palmitoyltransferase 1A |
CRISPR |
Clustered regularly interspaced short palindromic repeats |
Cytarabine |
Ara-C |
DHODH |
Dihydroorotate dehydrogenase |
ETC |
Electron transport chain |
F1P |
Fructose-1-phosphate |
FADH2 |
Flavin adenine dinucleotide |
FLT3-ITD |
Fms-like tyrosine kinase-3 internal tandem duplication |
G3P |
Glycerol-3-phosphate |
G6P |
Glucose-6-phosphate |
GLS |
Glutaminase |
GLUTs |
Glucose transporters |
GPX1 |
Glutathione peroxidase 1 |
GSH |
Glutathione |
GSR |
Glutathione-disulfide reductase |
HIF-1α |
Hypoxia-inducible factor 1-alpha |
HMG |
Hydroxy methylglutaryl |
HPLM |
Human plasma-like medium |
HSCs |
Haematopoietic stem cells |
IDH |
Isocitrate dehydrogenase |
LDHA |
Lactate dehydrogenase |
LSCs |
Leukaemic stem cells |
MCL-1 |
Myeloid Cell Leukaemia 1 |
mtDNA |
Mitochondrial DNA |
mTOR |
Mechanistic target of rapamycin |
NAD |
Nicotinamide adenine dinucleotide |
NADPH |
Nicotinamide adenine dinucleotide phosphate |
NSG |
NOD scid gamma mouse |
OAA |
Oxaloacetate |
OXPHOS |
Oxidative phosphorylation |
PEP |
Phosphoenolpyruvate |
PI3K |
Phosphoinositide 3-kinase |
PKM2 |
Pyruvate kinase M2 |
PPP |
Pentose phosphate pathway |
PUMA |
p53 upregulated modulator of apoptosis |
R5P |
Ribose-5-phosphate |
ROS |
Reactive oxygen species |
shRNA |
Short or small hairpin RNA |
SLCs |
Solute carriers |
TCA |
Tricarboxylic acid |