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. 2022 Jan 24;298(3):101630. doi: 10.1016/j.jbc.2022.101630

Figure 7.

Figure 7

CDCP1 potentiates HGF-induced accumulation of ARHGEF7 on the PIP3-enriched membrane domain.A, schematic diagram of ARHGEF7 structure. B, T47D cells expressing MET were transfected with the PH-Btk-EGFP construct and stimulated with or without HGF for 15 min. Subcellular localization of ARHGEF7 and PIP3 was visualized by immunofluorescence analysis. The scale bar represents 10 μm. C, T47D cells expressing MET and CDCP1 were stimulated with HGF for the indicated time and subjected to immunofluorescence staining for CDCP1 and ARHGEF7. The scale bar represents 10 μm and 2 μm (inset). D, MDA-MB-231 cells were stimulated with HGF for the indicated time and subjected to immunofluorescence staining for CDCP1 and ARHGEF7. The scale bar represents 10 μm and 2 μm (inset).