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Temperature dependence of relative amplitudes of the slow (SRX) phase of mantATP displacement from myofibrils. Percentage SRX for three different muscles; bovine masseter (A), rabbit psoas (B), and porcine ventricle (C) in the absence (white bars) of and presence (black bars) of mavacamten. The mavacamten used was influenced by the Kd determined in Figure 2. The concentration of mavacamten used was 3 μM for bovine masseter and porcine ventricle and 30 μM for rabbit psoas.
