Figure 5.

Temperature dependence of k_obsfor the fast and slow phase for the three tissue types in the absence of (open squares, fitted with solid lines) and in the presence of (closed triangles, fitted with dashed lines) mavacamten.A–C, Arrhenius plot of the fast phase k_obs. D–F, Arrhenius plot of the slow phase k_obs from the three tissue types in the absence of (open squares, fitted with solid lines) and presence of (open triangles, fitted with dashed lines) mavacamten (3 μM for bovine masseter and porcine ventricle and 30 μM for rabbit psoas). The values for ΔH^‡ and ΔS^‡ are summarized in Table 1.