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. 2022 Jan 25;298(3):101640. doi: 10.1016/j.jbc.2022.101640

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© 2022 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

Effect of mant-dATP/mant-ATP ratio on the displacement reaction for the three types of myofibrils. Myofibrils with increasing concentrations of mant-dATP from 0 to 100%. A, bovine masseter myofibrils. B, rabbit psoas myofibrils. C, porcine ventricle myofibrils (fast phase in white bars, and slow phase in black bars). For each myofibril type, the data for 100% mant-dATP + mavacamten are also shown. 3 μM mavacamten for bovine masseter and porcine ventricle, 30 μM mavacamten for rabbit psoas. The values for k_obs are summarized in Table S1.