Table 1.
Thermodynamic values from the Arrhenius and van't Hoff plots of the fast and slow phase data from Figures 4 and 5
| Myofibrils | Condition | Fast phase |
Slow phase |
Van't Hoff |
|||
|---|---|---|---|---|---|---|---|
| ΔH‡ (kJ.mol−1) | ΔS‡ (J.K.mol−1) | ΔH‡ (kJ.mol−1) | ΔS‡ (J.K.mol−1) | ΔH0 (kJ.mol−1) | ΔS0 (J.K.mol−1) | ||
| Bovine Masseter | − Mavacamten | 50.7 ± 4.2 | 143 ± 14.1 | 22.4 ± 9.1 | 31.6 ± 30.8 | −12.5 ± 7.5 | −51.5 ± 25.8 |
| + Mavacamten | 13.3 ± 10 | 16.6 ± 34.9 | 28.3 ± 5.8 | 50.7 ± 10.0 | −54.9 ± 6.7 | −182.9 ± 24.1 | |
| Rabbit Psoas | − Mavacamten | 44.1 ± 6.7 | 125.5 ± −24.1 | 30.8 ± 5.8 | 55.7 ± 20.8 | −4.2 ± 3.3 | −20.8 ± 11.6 |
| + Mavacamten | 45.7 ± 5.0 | 126.4 ± 17.5 | 10.0 ± 5.0 | −14.1 ± 18.3 | −27.4 ± 4.2 | −97.3 ± 14.1 | |
| Porcine Ventricle | − Mavacamten | 47.4 ± 4.2 | 138.8 ± 15.0 | 41.6 ± 13.3 | 93.9 ± 46.6 | −9.1 ± 9.1 | −44.1 ± 32.4 |
| + Mavacamten | 55.7 ± 10.0 | 162.1 ± 34.9 | 10.8 ± 4.2 | −6.7 ± 15.8 | −66.5 ± 6.7 | −225.3 ± 23.3 | |
ΔH‡, change in enthalpy; ΔS‡, change in entropy.