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. 2022 Jan 26;12:757228. doi: 10.3389/fendo.2021.757228

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Copyright © 2022 Martin, Chuah, Abdelaal, Pedersen, Malmodin, Abrahamsson, Hutter, Godson, Brennan, Fändriks, le Roux and Docherty

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Network visualisation of medication-responsive genes which were differentially expressed between the RYGB-FMRR and RYGB groups. The network was constructed using the ‘My Pathways’ interface in IPA, and edited using ‘PathDesigner’ in IPA. The four medications administered to rats treated with RYGB-FMRR, and their corresponding drug targets, are bolded. The legend outlines node symbols corresponding to molecule types contained within the network. The directionality of gene expression change in the RYGB-FMRR vs RYGB DEG list is displayed by node colour (red = upregulated; green = downregulated). Relationships between medications and their gene targets are illustrated by edge colour (orange = predicted activation; blue = predicted inhibition). DEG, differentially expressed gene; IPA, Ingenuity Pathway Analysis; RYGB, Roux-en-Y gastric bypass; RYGB-FMRR, Roux-en-Y gastric bypass plus fenofibrate, metformin, ramipril, and rosuvastatin.