Table 2.
Changes in body weight, plasma glucose, urinary albumin excretion, and serum lipids by experimental group.a,b,c
| Pre-post intervention comparisons (absolute values) d | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SD | SHAM | RYGB | RYGB-FMRR | |||||||||
| Pre | Post | p | Pre | Post | p | Pre | Post | p | Pre | Post | p | |
| Body weight (g) | 564.2±28.3 | 603.5±31.5 | 0.002 | 592.4±35.7 | 486.7±76.8 | 0.09 | 570.8±23.0 | 452.7±32.2 | <0.001 | 564.0±20.4 | 410.0±24.2 | <0.001 |
| Plasma glucose (mmol/L) | 5.3±0.2 | 6.0±1.0 | 0.12 | 13.3±6.4 | 23.2±11.5 | 0.06 | 13.0±4.3 | 11.7±7.5 | 0.30 | 13.4±4.9 | 6.2±1.7 | 0.007 |
| Log UAER (μg/hour) | 3.3±0.4 | 3.4±0.5 | 0.47 | 4.8±0.8 | 6.8±2.2 | 0.03 | 5.1±0.5 | 4.5±1.2 | 0.32 | 5.0±0.8 | 3.1±0.9 | 0.003 |
| Pre-post intervention comparisons (percentage delta change values) e | ||||||||||||
| Percentage delta change values | P-values for comparisons | |||||||||||
| SD | SHAM | RYGB | RYGB-FMRR | SHAM vs SD | RYGB vs SHAM | RYGB-FMRR vs SHAM | RYGB-FMRR vs RYGB | |||||
| Δ Body weight (%) | 7.0±2.7 | -8.3±10.5 | -20.7±4.7 | -27.3±3.8 | 0.01 | 0.02 | 0.008 | 0.01 | ||||
| Δ Plasma glucose (%) | 12.9±14.7 | 84.3±95.9 | -15.7±25.5 | -50.5±13.0 | 0.10 | 0.04 | 0.02 | 0.02 | ||||
| Δ Log UAER rate (%) | 3.3±9.5 | 37.2±30.3 | -10.6±22.8 | -36.4±17.5 | 0.03 | 0.01 | 0.001 | 0.03 | ||||
| Study close comparisons e | ||||||||||||
| Study close values | P-values for comparisons | |||||||||||
| SD | SHAM | RYGB | RYGB-FMRR | SHAM vs SD | RYGB vs SHAM | RYGB-FMRR vs SHAM | RYGB-FMRR vs RYGB | |||||
| Serum cholesterol (mmol/L) | 1.78±0.11 | 2.66±0.42 | 2.15±0.26 | 2.26±0.19 | 0.004 | 0.04 | 0.07 | 0.33 | ||||
| Serum triglycerides (mmol/L) | 0.85±0.19 | 2.37±1.43 | 1.13±0.21 | 1.08±0.38 | 0.08 | 0.08 | 0.08 | 0.81 | ||||
RYGB, Roux-en-Y gastric bypass; RYGB-FMRR, Roux-en-Y gastric bypass plus fenofibrate, metformin, ramipril, and rosuvastatin; SD, Sprague Dawley; SHAM, sham surgery (laparotomy); UAER, urinary albumin excretion rate.
Body weight was assessed at 8 weeks after intervention, while plasma glucose and urinary albumin excretion were assessed at 4 weeks post-intervention.
Values are given as mean ± SD.
Statistical significance of within-group differences are derived from multiplicity-corrected (Benjamini-Hochberg) paired t-tests.
Statistical significance of between-group differences are derived from multiplicity-corrected (Benjamini-Hochberg) unpaired t-tests.