Table 3.
Multivariate Cox proportional hazards regression models for metastasis-free survival including prostate-specific antigen nadir (nPSA) and time to nPSA in 186 patients treated with EBRT combined with BT boost and ADT for localized prostate cancer
| Level | Model 1 | Model 2 | Model 3 | ||||
|---|---|---|---|---|---|---|---|
| HR (95% CI) | p-value | HR (95% CI) | p-value | HR (95% CI) | p-value | ||
| TNM | > T1c vs. T1c | 3.92 (0.92-16.67) | 0.065 | 3.6 (0.85-15.39) | 0.083 | 0.26 (0.06-1.08) | 0.065 |
| Gleason grade group | 3/4 vs. 1/2 | 2.29 (0.64-8.16) | 0.199 | 2.1 (0.61-7.46) | 0.234 | 1.75 (0.50-6.03) | 0.379 |
| 5 vs. 1/2 | 3.98 (1.51-10.46) | 0.005 | 4.6 (1.78-12.12) | 0.002 | 4.61 (1.78-11.88) | 0.002 | |
| PSAmax (ng/ml) | 0.99 (0.99-1.00) | 0.476 | 0.99 (0.99-1.00) | 0.159 | 0.99 (0.99-1.00) | 0.462 | |
| nPSA (10 ng/ml) | – | – | 1.1 (1.07-1.17) | < 0.001 | – | – | |
| nPSA < 0.2 (ng/ml) | Yes vs. No | 0.25 (0.11-0.58) | 0.001 | – | – | – | – |
| C-index: 0.78 AIC: 224.0989 |
C-index: 0.8 AIC: 218.6099 |
C-index: 0.68 AIC: 230.905 |
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Gleason grade group – International Society of Urological Pathology 2014 grade group system; nPSA – PSA nadir; C-index – Harrell’s concordance index; AIC – Akaike information criterion