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. 2021 Jun 25;77(3):283–291. doi: 10.1136/thoraxjnl-2020-216179

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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The lung microbiome is altered in patients with invasive pulmonary aspergillosis (IPA). (A) Relative abundance (%) of operational taxonomical units assigned at the phylum and genus levels in each bronchoalveolar lavage sample from the overall cohort. (B) Principal coordinate analysis of cases of IPA and controls based on the Bray-Curtis dissimilarity metric and the Jaccard distance. Axes represent the first two principal coordinates, with the variation explained by the indicated variable shown as percentage. (C) Boxplots illustrating the alpha diversity (measured by the Shannon and Simpson Diversity Indexes) and the species richness of the lung microbiome in cases of IPA and controls. Median values and IQRs are indicated in the plots.