Table 1.
Baseline characteristics of participants according to diagnosed dementia at follow-up
| Variables | Dementia | |||
| No | Yes | P value | ||
| Age at baseline | Mean (SD) | 64.1 (2.8) | 65.8 (2.7) | <0.001 |
| Sex | Female | 79 816 (52.0) | 631 (43.7) | <0.001 |
| Male | 73 803 (48.0) | 813 (56.3) | ||
| Education | Lower | 40 575 (26.7) | 536 (38.2) | <0.001 |
| Intermediate | 71 838 (47.4) | 606 (43.2) | ||
| Higher | 39 304 (25.9) | 261 (18.6) | ||
| Long-term illness | No | 57 734 (38.7) | 319 (23.3) | <0.001 |
| Yes | 91 264 (61.3) | 1053 (76.7) | ||
| Physical activity | Low | 45 961 (30.7) | 479 (34.9) | 0.001 |
| High | 103 933 (69.3) | 893 (65.1) | ||
| Current smoker | No | 140 640 (92.0) | 1281 (89.4) | <0.001 |
| Yes | 12 264 (8.0) | 152 (10.6) | ||
| Alcohol consumption | Lower | 81 237 (52.9) | 866 (60.1) | <0.001 |
| Higher | 72 281 (47.1) | 575 (39.9) | ||
| Depressive symptoms | Low | 121 502 (82.5) | 1014 (75.8) | <0.001 |
| Low medium | 21 350 (14.5) | 245 (18.3) | ||
| High medium | 2788 (1.9) | 42 (3.1) | ||
| High | 1639 (1.1) | 37 (2.8) | ||
| Townsend deprivation index | Mean (SD) | −1.7 (2.8) | −1.1 (3.3) | <0.001 |
| Socially isolated | No | 138 407 (91.5) | 1208 (87.3) | <0.001 |
| Yes | 12 922 (8.5) | 175 (12.7) | ||
| Feeling lonely | No | 138 250 (94.5) | 1253 (92.5) | 0.001 |
| Yes | 7999 (5.5) | 102 (7.5) | ||
| Genetic dementia risk | Low | 51 355 (33.4) | 333 (23.1) | <0.001 |
| Intermediate | 51 171 (33.3) | 517 (35.8) | ||
| High | 51 093 (33.3) | 594 (41.1) | ||
| Apolipoprotein E genotype | None | 113 994 (74.2) | 707 (49.0) | <0.001 |
| One e4 allele | 36 103 (23.5) | 568 (39.3) | ||
| Two e4 alleles | 3522 (2.3) | 169 (11.7) | ||