Table 3.
Summary of risk of bias across SNPs and outcomes following omega-3 exposure/intervention
| Study | Risk of bias |
| CD36, rs1761667 and HDL-c | |
| Dawczynski et al80 | ⊝ |
| Madden et al79 | ⊝ |
| CD36, rs1761667 and TG | |
| Dawczynski et al80 | ⊝ |
| Madden et al79 | ⊝ |
| CD36, rs1049673 and HDL-c | |
| Dawczynski et al80 | ⊝ |
| Madden et al79 | ⊝ |
| CD36, rs1527483 and TG | |
| Zheng et al65 | ⊕ |
| Madden et al79 | ⊝ |
| ApoE, rs429358, rs7412 and TG | |
| AbuMweis et al69 | ⊝ |
| Carvalho-Wells et al70 | ⊕ |
| Caslake et al71 | ⊕ |
| Dang et al72 | ⊕ |
| Jackson et al73 | ⊝ |
| Minihane et al75 | ⊕ |
| Olano-Martin et al76 | ⊕ |
| Paschos et al77 | ⊝ |
| Thifault et al78 | ⊕ |
| ApoE, rs429358, rs7412 and total-c | |
| AbuMweis et al69 | ⊝ |
| Carvalho-Wells et al70 | ⊕ |
| Caslake et al71 | ⊕ |
| Dang et al72 | ⊕ |
| Fallaize et al54 | ⊝ |
| Jackson et al73 | ⊝ |
| Minihane et al75 | ⊕ |
| Olano-Martin et al76 | ⊕ |
| Paschos et al77 | ⊝ |
| Thifault et al78 | ⊕ |
| 31-SNP nutri-GRS and TG | |
| Vallée Marcotte et al63 | ⊕ |
| Vallée Marcotte et al64 | ⊕ |
| PPARg2, rs1801282 and LDL-c | |
| Binia et al81 | ⊝ |
| Harsløf et al61 | ⊕ |
| Itariu et al84 | ⊕ |
| Lindi et al85 | ⊝ |
| Zheng et al65 | ⊕ |
| PPARg2, rs1801282 and total-c | |
| Binia et al81 | ⊝ |
| Harsløf et al61 | ⊕ |
| Itariu et al84 | ⊕ |
| Lindi et al85 | ⊝ |
| Zheng et al65 | ⊕ |
| PPARg2, rs1801282 and TG | |
| Binia et al81 | ⊝ |
| Harsløf et al61 | ⊕ |
| Itariu et al84 | ⊕ |
| Lindi et al85 | ⊝ |
| Zheng et al65 | ⊕ |
| FADS, rs174547 and total-c | |
| AbuMweis et al69 | ⊝ |
| Alsaleh et al60 | ⊕ |
| Lu et al46 | ⊝ |
| Standl et al47 | ⊝ |
| Dumont et al43 | ⊝ |
| Dumont et al44 | ⊝ |
| Roke and Mutch67 | ⊝ |
⊕ no serious risk of bias; ⊝ serious risk of bias; ⊝⊝ very serious risk of bias (for study design type using NIH Study Quality Assessment Tools).
GRSs, genetic risk scores; HDL-c, high-density lipoprotein cholesterol; LDL-c, low-density lipoprotein cholesterol; SNPs, single nucleotide polymorphisms; TG, triglycerides; total-c, total cholesterol.