Table 3.
Proportions of HC users and non-users receiving one or more prescriptions of psychotropic medications between 2013 and 2016, as number of prescriptions (left side) or levels of use (based on quantiles of redeemed DDD) (right side)
| Class of psychotropic medication | Number of prescriptions | HC users | HC non-users | P value* | Level of use† | HC users | HC non-users | P value* |
| Any psychotropic medication | 0.0001 | |||||||
| One prescription | 13 269 (4.5%) | 12 696 (4.3%) | 0.0008 | – | – | – | – | |
| ≥2 prescriptions | 43 572 (14.8%) | 43 072 (14.6%) | 0.179 | – | – | – | – | |
| Antipsychotics | <0.0001 | <0.0001 | ||||||
| One prescription | 3867 (1.5%) | 4273 (1.3%) | <0.0001 | Low | 5445 (1.85%) | 5709 (1.94%) | 0.037 | |
| Intermediate | 4385 (1.49%) | 4734 (1.61%) | 0.0008 | |||||
| ≥2 prescriptions | 10 548 (3.6%) | 11 694 (4.0%) | <0.0001 | High | 4582 (1.56%) | 5519 (1.88%) | <0.0001 | |
| Anxiolytics | 0.011 | 0.0013 | ||||||
| One prescription | 6748 (2.3%) | 6564 (2.2%) | 0.222 | Low | 4852 (1.65%) | 4650 (1.58%) | 0.115 | |
| Intermediate | 4503 (1.53%) | 4506 (1.53%) | 2.924 | |||||
| ≥2 prescriptions | 6705 (2.3%) | 7001 (2.4%) | 0.023 | High | 4.098 (1.39%) | 4409 (1.50%) | 0.0022 | |
| Hypnotics/sedatives | <0.0001 | <0.0001 | ||||||
| One prescription | 6786 (2.3%) | 6072 (2.1%) | <0.0001 | Low | 6865 (2.33%) | 6134 (2.08%) | <0.0001 | |
| ≥2 prescriptions | 6321 (2.2%) | 5493 (1.9%) | <0.0001 | High | 6232 (2.12%) | 5407 (1.84%) | <0.0001 | |
| Antidepressants | 0.053 | 0.088 | ||||||
| One prescription | 8395 (2.9%) | 8460 (2.9%) | 1.233 | Low | 14 815 (2.52%) | 14 867 (2.53%) | 2.288 | |
| Intermediate | 14 998 (2.55%) | 14 689 (2.50%) | 0.219 | |||||
| ≥2 prescriptions | 36 396 (12.4%) | 35 793 (12.2%) | 0.050 | High | 14 978 (2.54%) | 14 697 (2.50%) | 0.308 | |
| Psychostimulants | 0.11 | 0.052 | ||||||
| One prescription | 236 (0.08%) | 276 (0.09%) | 0.154 | Low | 617 (0.21%) | 702 (0.24%) | 0.058 | |
| Intermediate | 563 (0.19%) | 612 (0.21%) | 0.459 | |||||
| ≥2 prescriptions | 1604 (0.6%) | 1669 (0.6%) | 0.512 | High | 617 (0.21%) | 602 (0.21%) | 2.003 | |
| Psycholeptics–psychoanaleptics in combination | <0.0001 | <0.0001 | ||||||
| One prescription | 809 (0.28%) | 673 (0.23%) | 0.0008 | Low | 804 (0.27%) | 658 (0.22%) | 0.0003 | |
| ≥2 prescriptions | 697 (0.24%) | 538 (0.18%) | <0.0001 | High | 702 (0.24%) | 553 (0.19%) | <0.0001 |
*P values are from overall χ2 tests, and from post hoc pairwise comparisons adjusted for multiple testing.
†Level of use of psychotropic medications was based on quantiles of purchased DDD (tertiles for antipsychotics, anxiolytics, antidepressants and psychostimulants; 50th percentile for hypnotics/sedatives, and 60th percentile for psycholeptics and psychoanaleptics in combination).
ATC, Anatomical Therapeutic Chemical; DDD, defined daily dose; HC, hormonal contraception.