Table 4.
Class of psychotropic medication | Number of prescriptions | Model 1 | Model 2 | Model 3 | Model 4 | ||||||||
OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | OR | 95% CI | P value | ||
Any psychotropic medication | One prescription | 1.05 | 1.02 to 1.08 | 0.0001 | 1.06 | 1.04 to 1.09 | <0.0001 | 1.04 | 1.01 to 1.06 | 0.0072 | 1.03 | 1.01 to 1.06 | 0.014 |
≥2 prescriptions | 1.02 | 1.00 to 1.03 | 0.0295 | 1.04 | 1.03 to 1.06 | <0.0001 | 1.08 | 1.06 to 1.09 | <0.0001 | 1.07 | 1.06 to 1.09 | <0.0001 | |
Antipsychotics | One prescription | 0.90 | 0.86 to 0.94 | <0.0001 | 0.95 | 0.91 to 1.00 | 0.0335 | 0.96 | 0.92 to 1.01 | 0.104 | 0.96 | 0.92 to 1.00 | 0.069 |
≥2 prescriptions | 0.90 | 0.88 to 0.92 | <0.0001 | 0.97 | 0.94 to 1.00 | 0.0198 | 1.06 | 1.03 to 1.09 | 0.0001 | 1.06 | 1.03 to 1.09 | 0.0002 | |
Anxiolytics | One prescription | 1.03 | 0.99 to 1.06 | 0.121 | 1.04 | 1.00 to 1.08 | 0.0295 | 1.04 | 1.01 to 1.08 | 0.0214 | 1.04 | 1.00 to 1.07 | 0.055 |
≥2 prescriptions | 0.96 | 0.93 to 0.99 | 0.0117 | 1.02 | 0.98 to 1.05 | 0.309 | 1.10 | 1.06 to 1.14 | <0.0001 | 1.10 | 1.06 to 1.14 | <0.0001 | |
Hypnotics/ sedatives | One prescription | 1.12 | 1.09 to 1.16 | <0.0001 | 1.12 | 1.08 to 1.16 | <0.0001 | 1.09 | 1.05 to 1.13 | <0.0001 | 1.09 | 1.05 to 1.13 | <0.0001 |
≥2 prescriptions | 1.16 | 1.12 to 1.20 | <0.0001 | 1.16 | 1.11 to 1.20 | <0.0001 | 1.18 | 1.14 to 1.23 | <0.0001 | 1.19 | 1.15 to 1.24 | <0.0001 | |
Antidepressants | One prescription | 1.00 | 0.96 to 1.03 | 0.724 | 1.02 | 0.99 to 1.06 | 0.165 | 1.01 | 0.98 to 1.04 | 0.479 | 1.01 | 0.98 to 1.04 | 0.575 |
≥2 prescriptions | 1.02 | 1.00 to 1.04 | 0.0178 | 1.04 | 1.03 to 1.06 | <0.0001 | 1.07 | 1.06 to 1.09 | <0.0001 | 1.07 | 1.06 to 1.09 | <0.0001 | |
Psychostimulants | One prescription | 0.86 | 0.72 to 1.02 | 0.077 | 0.92 | 0.77 to 1.09 | 0.323 | 0.95 | 0.79 to 1.13 | 0.535 | 0.94 | 0.79 to 1.13 | 0.510 |
≥2 prescriptions | 0.96 | 0.90 to 1.03 | 0.252 | 1.03 | 0.96 to 1.10 | 0.405 | 1.05 | 0.98 to 1.12 | 0.213 | 1.04 | 0.97 to 1.12 | 0.247 | |
Psycholeptics and psychoanaleptics | One prescription | 1.20 | 1.09 to 1.33 | 0.0004 | 1.19 | 1.07 to 1.32 | 0.0012 | 1.17 | 1.06 to 1.30 | 0.0025 | 1.18 | 1.06 to 1.31 | 0.0024 |
≥2 prescriptions | 1.30 | 1.16 to 1.45 | <0.0001 | 1.31 | 1.17 to 1.47 | <0.0001 | 1.35 | 1.21 to 1.52 | <0.0001 | 1.37 | 1.22 to 1.53 | <0.0001 |
Model 1 is the unadjusted model; Model 2 is Model 1 adjusted for age group, education and marital status; Model 3 is Model 2 adjusted for socioeconomic status and income level; Model 4 is Model 3 adjusted for recent pregnancy (in 2017), abortion (in 2016–2017) and sterilisation (before 2017).
HC, hormonal contraception.