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. 2022 Feb 22;12(2):e053837. doi: 10.1136/bmjopen-2021-053837

Table 4.

Associations between number of prescriptions of psychotropic medications between 2013 and 2016, and hormonal contraception use in 2017

Class of psychotropic medication Number of prescriptions Model 1 Model 2 Model 3 Model 4
OR 95% CI P value OR 95% CI P value OR 95% CI P value OR 95% CI P value
Any psychotropic medication One prescription 1.05 1.02 to 1.08 0.0001 1.06 1.04 to 1.09 <0.0001 1.04 1.01 to 1.06 0.0072 1.03 1.01 to 1.06 0.014
≥2 prescriptions 1.02 1.00 to 1.03 0.0295 1.04 1.03 to 1.06 <0.0001 1.08 1.06 to 1.09 <0.0001 1.07 1.06 to 1.09 <0.0001
Antipsychotics One prescription 0.90 0.86 to 0.94 <0.0001 0.95 0.91 to 1.00 0.0335 0.96 0.92 to 1.01 0.104 0.96 0.92 to 1.00 0.069
≥2 prescriptions 0.90 0.88 to 0.92 <0.0001 0.97 0.94 to 1.00 0.0198 1.06 1.03 to 1.09 0.0001 1.06 1.03 to 1.09 0.0002
Anxiolytics One prescription 1.03 0.99 to 1.06 0.121 1.04 1.00 to 1.08 0.0295 1.04 1.01 to 1.08 0.0214 1.04 1.00 to 1.07 0.055
≥2 prescriptions 0.96 0.93 to 0.99 0.0117 1.02 0.98 to 1.05 0.309 1.10 1.06 to 1.14 <0.0001 1.10 1.06 to 1.14 <0.0001
Hypnotics/ sedatives One prescription 1.12 1.09 to 1.16 <0.0001 1.12 1.08 to 1.16 <0.0001 1.09 1.05 to 1.13 <0.0001 1.09 1.05 to 1.13 <0.0001
≥2 prescriptions 1.16 1.12 to 1.20 <0.0001 1.16 1.11 to 1.20 <0.0001 1.18 1.14 to 1.23 <0.0001 1.19 1.15 to 1.24 <0.0001
Antidepressants One prescription 1.00 0.96 to 1.03 0.724 1.02 0.99 to 1.06 0.165 1.01 0.98 to 1.04 0.479 1.01 0.98 to 1.04 0.575
≥2 prescriptions 1.02 1.00 to 1.04 0.0178 1.04 1.03 to 1.06 <0.0001 1.07 1.06 to 1.09 <0.0001 1.07 1.06 to 1.09 <0.0001
Psychostimulants One prescription 0.86 0.72 to 1.02 0.077 0.92 0.77 to 1.09 0.323 0.95 0.79 to 1.13 0.535 0.94 0.79 to 1.13 0.510
≥2 prescriptions 0.96 0.90 to 1.03 0.252 1.03 0.96 to 1.10 0.405 1.05 0.98 to 1.12 0.213 1.04 0.97 to 1.12 0.247
Psycholeptics and psychoanaleptics One prescription 1.20 1.09 to 1.33 0.0004 1.19 1.07 to 1.32 0.0012 1.17 1.06 to 1.30 0.0025 1.18 1.06 to 1.31 0.0024
≥2 prescriptions 1.30 1.16 to 1.45 <0.0001 1.31 1.17 to 1.47 <0.0001 1.35 1.21 to 1.52 <0.0001 1.37 1.22 to 1.53 <0.0001

Model 1 is the unadjusted model; Model 2 is Model 1 adjusted for age group, education and marital status; Model 3 is Model 2 adjusted for socioeconomic status and income level; Model 4 is Model 3 adjusted for recent pregnancy (in 2017), abortion (in 2016–2017) and sterilisation (before 2017).

HC, hormonal contraception.