Table 1. Baseline Patient Characteristics.
| Characteristic | Data (N = 169)a |
|---|---|
| Age, mean (SD), y | 36.3 (15.0) |
| Sex | |
| Men | 95 (56.2) |
| Women | 74 (43.8) |
| Proband status | 128/169 (75.7) |
| 2010 TFC fulfillment | |
| Class I: morphology | |
| Major | 78 (46.2) |
| Minor | 35 (20.7) |
| Class II: tissue characterization | |
| Major | 27 (16.0) |
| Minor | 5 (3.0) |
| Class III: repolarization abnormalities | |
| Major | 89 (52.7) |
| Minor | 50 (29.6) |
| Class IV: depolarization abnormalities | |
| Major | 9 (5.3) |
| Minor | 46 (27.2) |
| Class V: arrhythmias | |
| Major | 31 (18.3) |
| Minor | 101 (59.8) |
| Class VI: family history | |
| Major | 96 (56.8) |
| Minor | 13 (7.7) |
| Pathogenic/likely pathogenic variation | 85 (50.3) |
| PKP2 | 54 (32.0) |
| DSP | 19 (11.2) |
| DSG2 | 8 (4.7) |
| DES | 2 (1.2) |
| FLNC | 2 (1.2) |
| Recent cardiac syncope | 24 (14.2) |
| TWI, median (IQR) | 3 (2-4) |
| NSVT at diagnosis | 61 (36.1) |
| 24-h PVC count, median (IQR) | 5852 (4409-7295) |
| History of sustained ventricular tachycardia at diagnosis | 47 (27.8) |
| RVEF at CMR, mean (SD), % | 46.0 (12.2) |
| Treatment at baseline | |
| β-Blockers | 86 (50.9) |
| AADs | 39 (23.1) |
| Sotalolo | 36 (21.3) |
| Class Ic | 6 (3.5) |
| Amiodarone hydrochloride | 3 (1.8) |
| ICD | 73 (43.2) |
Abbreviations: AADs, antiarrhythmic drugs; CMR, cardiac magnetic resonance; DES, desmin; DSG2, desmoglein 2; DSP, desmoplakin; FLNC, filamin C; ICD, implantable cardioverter-defibrillator; NSVT, nonsustained ventricular tachycardia; PKP2, plakophylin 2; PVC, premature ventricular complex; RVEF, right ventricular ejection fraction; TFC, Task Force Criteria; TWI, T-wave inversion.
a
Unless otherwise indicated, data are expressed as number (%) of patients.