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. Author manuscript; available in PMC: 2022 Jun 8.
Published in final edited form as: Nature. 2021 Dec 8;600(7890):759–764. doi: 10.1038/s41586-021-04175-x

Extended Data Table 3 |.

Measured pharmacokinetic parameters for PB28, Z1665845742, Z4446724338 and Z4857158944 in male CD-1 mice by 10 mg/kg subcutaneous administration

Pharmacokinetic Parameters
Type Name Tmax min Cmax ng/ml (g) AUC0→t (AUClast) ng*min/ml (g) AUC0→∞ (AUCinf_obs) ng*min/ml (g) T1/2 (HL_Lambda_z), min Kel (Lambda_z), min−1
Plasma Z1665845742 20 968 99000 112000 185 0.00374
Z4446724338 20 449 58300 60500 47.4 0.0146
Z4857158944 20 228 13300 14200 27.8 0.0249
PB28 60 42 8640 45900 740 0.000937
Brain Z1665845742 20 3150 436000 509000 747 0.000928
Z4446724338 20 7390 1140000 1150000 69.7 0.00995
Z4857158944 20 2960 247000 327000 452 0.00153
PB28 60 948 229000 240000 98.1 0.00706