Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Feb 8;12:820463. doi: 10.3389/fendo.2021.820463

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2022 Zhao, Chen, Liu, Jiang, Chen, Chen, Song, Tao, Cui, Li, Zhu, Chen, Hu and Luo

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Schematic diagram showing the main events related to the testis and brain involved in the HPG axis across testicular differentiation and maturation inferring from the results of this study. GnRH3, Gonadotropin-releasing hormone; Kiss2, Kisspeptin2; Kiss1r, Kisspeptin1r; GHRH-LR, pituitary adenylate cyclase-activating polypeptide type I receptor-like; SCG2a/b, Secretoneurin II a/b; OXT, isotocin; GAD1/2, γ-aminobutyric acid; NPY, neuropeptide Y; TAC1/3, Tachykinin 1/3; Cyp11b, Cytochrome P450 family 11 subfamily B polypeptide; Hsd17b2, Hydroxysteroid 17-Beta dehydrogenase B2; Hsd17b3, Hydroxysteroid 17-Beta dehydrogenase B3. FSH, follicle-stimulating hormone; LH, luteinizing hormone. the transcription factor. The expression values were represented by FPKM/z-score. Ovals represent the transcription factors. The GnRH in the brain stimulates the secretion of pituitary gonadotropins, FSH, and LH, which in-turn act on the testes to stimulate the production of sex steroid hormones.