Table 1.
Clinicopathologic characteristics of IgAN patients in low and high Hcy group
| Variable | Total (n = 337) | Hcy ≤ 10.0 (n = 114) | Hcy > 10.0 (n = 223) | P |
|---|---|---|---|---|
| Hcy (μmol/L) | 11.6 (9.1,15.3) | 8.2 (7.3,9.1) | 13.7 (11.7,16.7) | < 0.001** |
| Age (years) | 34.0 (27.5,44.0) | 32.5 (27.0,39.0) | 35.0 (28.0,47.0) | 0.003* |
| Male, n (%) | 135 (40.1) | 27 (23.7) | 108 (48.4) | < 0.001** |
| SBP (mmHg) | 123.0 (115.0,137.5) | 119.5 (110.0,131.0) | 126.0 (117.0,141.0) | < 0.001** |
| DBP (mmHg) | 80.0 (74.0,90.0) | 77.5 (73.0,87.0) | 82.0 (75.0,94.0) | 0.002* |
| MAP (mmHg) | 94.7 (88.7,106.3) | 92.0 (86.3,99.7) | 96.3 (89.3,109.7) | < 0.001** |
| HBP, n (%) | 132 (39.2) | 22 (19.3) | 110 (49.3) | < 0.001** |
| Scr (μmol/L) | 86.0 (70.0,115.5) | 69.5 (61.0,82.3) | 99.0 (77.0,139.0) | < 0.001** |
| eGFR (mL/min/1.73 m2) | 88.1 (62.8,103.4) | 101.4 (89.3,115.4) | 75.0 (44.9,95.2) | < 0.001** |
| CKD stage, n (%) | < 0.001** | |||
| CKD 1 | 156 (46.3) | 82 (71.9) | 74 (33.2) | |
| CKD 2 | 100 (29.7) | 32 (28.1) | 68 (30.5) | |
| CKD 3 | 51 (15.1) | 0 (0.0) | 51 (22.9) | |
| CKD 4 | 13 (3.9) | 0 (0.0) | 13 (5.8) | |
| CKD 5 | 17 (5.0) | 0 (0.0) | 17 (7.6) | |
| BUN (mmol/L) | 5.1 (4.3,6.9) | 4.5 (3.6,5.1) | 5.8 (4.7,8.0) | < 0.001** |
| UA (mmol/L) | 390.0 (324.0,484.5) | 352.5 (302.8,413.8) | 413.0 (347.0,512.0) | < 0.001** |
| 24-h urine protein (g/24 h) | 0.6 (0.2,1.7) | 0.5 (0.2,1.0) | 0.7 (0.3,1.8) | 0.101 |
| Hb (g/L) | 125.0 (114.0,139.5) | 128.5 (118.8,138.0) | 124.0 (111.0,142.0) | 0.135 |
| ALB (g/L) | 35.0 ± 6.8 | 33.7 ± 7.9 | 35.6 ± 6.2 | 0.011* |
| Glu (mmol/L) | 4.4 ± 0.6 | 4.4 ± 0.5 | 4.4 ± 0.6 | 0.631 |
| CHOL (mmol/L) | 5.1 (4.3,5.9) | 5.1 (4.5,6.0) | 5.0 (4.3,5.9) | 0.262 |
| TG (mmol/L) | 1.6 ± 1.4 | 1.4 ± 0.9 | 1.7 ± 1.6 | 0.080 |
| LDL (mmol/L) | 3.2 (2.6,3.8) | 3.2 (2.7,3.9) | 3.2 (2.6,3.8) | 0.386 |
| HDL (mmol/L) | 1.3 ± 0.4 | 1.4 ± 0.4 | 1.2 ± 0.3 | < 0.001** |
| SOD (U/ml) | 136.0 ± 26.6 | 138.4 ± 30.3 | 134.8 ± 24.5 | 0.241 |
| hsCRP (mg/L) | 0.7 (0.3,1.8) | 0.5 (0.3,1.5) | 0.8 (0.3,2.0) | 0.033* |
| ESR (mm/h) | 17.0 (9.0,32.0) | 16.5 (10.0,27.0) | 19.0 (8.0,35.0) | 0.647 |
| IgA (g/L) | 3.3 ± 1.1 | 3.3 ± 1.1 | 3.3 ± 1.2 | 0.695 |
| IgM (g/L) | 1.2 ± 0.6 | 1.3 ± 0.6 | 1.2 ± 0.5 | 0.024* |
| IgG (g/L) | 11.5 ± 3.3 | 11.0 ± 3.5 | 11.7 ± 3.2 | 0.066 |
| C3 (mg/L) | 1054.2 ± 202.2 | 1077.9 ± 213.5 | 1042.0 ± 195.7 | 0.125 |
| C4 (mg/L) | 258.4 ± 91.6 | 250.9 ± 91.1 | 262.2 ± 91.9 | 0.288 |
| Oxford classification, n (%) | ||||
| M1 | 320 (95.0) | 108 (94.7) | 212 (95.1) | 0.896 |
| E1 | 65 (19.3) | 15 (13.2) | 50 (22.4) | 0.041* |
| S1 | 132 (39.2) | 42 (36.8) | 90 (40.4) | 0.531 |
| T | < 0.001** | |||
| T0 | 238 (70.6) | 106 (93.0) | 132 (59.2) | |
| T1 | 70 (20.8) | 7 (6.1) | 63 (28.3) | |
| T2 | 29 (8.6) | 1 (0.9) | 28 (12.6) | |
| C | 0.524 | |||
| C0 | 150 (44.5) | 54 (47.4) | 96 (43.0) | |
| C1 | 166 (49.3) | 55 (48.2) | 111 (49.8) | |
| C2 | 21 (6.2) | 5 (4.4) | 16 (7.2) | |
Abbreviations: Hcy homocysteine, SBP systolic blood pressure, DBP diastolic blood pressure, MAP mean arterial pressure, HBP Hypertension, Scr serum creatinine, eGFR estimated glomerular filtration rate, CKD chronic kidney disease, BUN blood urine nitrogen, UA uric acid, Hb hemoglobin, ALB serum albumin, Glu fasting glucose, CHOL cholesterol, TG triglyceride, LDL low-density lipoprotein-cholesterol, HDL high-density lipoprotein-cholesterol, SOD superoxide dismutase, hsCRP high sensitivity C reaction protein, ESR erythrocyte sedimentatio rate, IgA immunoglobulin A, IgM immunoglobulin M, IgG immunoglobulin G, C3 complement3, C4 complement4, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental glomerulosclerosis, T tubular atrophy and interstitial fibrosis, C crescents
*P < 0.05, **P < 0.001