Table 3.
Clinicopathologic features as factors of elevated Hcy by univariate and multivariate logistic regression analysis
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| Overall | eGFR≥90 ml/min/1.73 m2 | |||||
| Odds ratio (95% CI) | P | Odds ratio (95% CI) | P | Odds ratio (95%CI) | P | |
| Age | 1.04 (1.02-1.06) | < 0.001** | ||||
| Male | 3.03 (1.83-5.02) | < 0.001** | 3.47 (1.86-6.48) | < 0.001** | 5.31 (2.23-12.64) | < 0.001** |
| MAP | 1.04 (1.02-1.05) | < 0.001** | ||||
| Scr | 1.07 (1.05-1.09) | < 0.001** | ||||
| eGFR | 0.95 (0.94-0.96) | < 0.001** | 0.95 (0.94-0.97) | < 0.001** | 0.95 (0.91-0.98) | 0.003* |
| BUN | 1.66 (1.40-1.98) | < 0.001** | ||||
| UA | 1.01 (1.00-1.01) | < 0.001** | ||||
| 24-h urine protein | 1.00 (0.94-1.08) | 0.929 | ||||
| Hb | 0.99 (0.98-1.00) | 0.085 | ||||
| ALB | 1.04 (1.01-1.08) | 0.013* | 1.07 (1.03-1.12) | 0.001* | 1.10 (1.04-1.16) | 0.001* |
| Glu | 0.91 (0.60-1.36) | 0.630 | ||||
| CHOL | 0.87 (0.77-1.00) | 0.042* | ||||
| TG | 1.24 (0.98-1.58) | 0.079 | ||||
| LDL | 0.83 (0.69-1.01) | 0.061 | ||||
| HDL | 0.31 (0.16-0.61) | 0.001* | ||||
| SOD | 1.00 (0.99-1.00) | 0.241 | ||||
| hsCRP | 1.01 (0.98-1.04) | 0.429 | ||||
| ESR | 1.01 (1.00-1.02) | 0.033* | ||||
| Ig A | 1.04 (0.85-1.28) | 0.694 | ||||
| Ig M | 0.63 (0.42-0.95) | 0.027* | ||||
| Ig G | 1.07 (1.00-1.14) | 0.068 | ||||
| C3 | 1.00 (1.00-1.00) | 0.126 | ||||
| C4 | 1.00 (1.00-1.00) | 0.288 | ||||
| M0 | 1 (reference) | |||||
| M1 | 1.07 (0.39-2.97) | 0.896 | ||||
| E0 | 1 (reference) | |||||
| E1 | 1.91 (1.02-3.57) | 0.044* | ||||
| S0 | 1 (reference) | |||||
| S1 | 1.16 (0.73-1.85) | 0.532 | ||||
| T0 | 1 (reference) | 1 (reference) | 1 (reference) | |||
| T1-2 | 9.13 (4.24-19.66) | < 0.001** | 2.87 (1.20-6.89) | 0.018* | 14.20 (1.68-120.03) | 0.015* |
| C0 | 1 (reference) | |||||
| C1-2 | 1.19 (0.76-1.87) | 0.451 | ||||
Abbreviations: MAP mean arterial pressure, Scr serum creatinine, eGFR estimated glomerular filtration rate, BUN blood urine nitrogen, UA uric acid, Hb hemoglobin, ALB serum albumin, Glu fasting glucose, CHOL cholesterol, TG triglyceride, LDL low-density lipoprotein-cholesterol, HDL high-density lipoprotein-cholesterol, SOD superoxide dismutase, hsCRP high sensitivity C reaction protein, ESR erythrocyte sedimentatio rate, IgA immunoglobulin A, IgM immunoglobulin M, IgG immunoglobulin G, C3 complement3, C4 complement4, M mesangial hypercellularity, E endocapillary hypercellularity, S segmental glomerulosclerosis, T tubular atrophy and interstitial fibrosis, C crescents
*P < 0.05, **P < 0.001