Fig. 1.

LINC00930 is a metabolism-related lncRNA and clinically relevant with the progression of NPC. a Experimental scheme for identifying lncRNAs potentially involved in both cell viability and glucose metabolism in NPC. b Five lncRNAs regulated both cell proliferation and lactate production in 5-8F cell (n = 3 biologically independent samples). c Statistical analysis of LINC00930 expression in normal, SM, DYS, and NPC tissues. (n = 40, nonparametric Mann-Whitney test). SM, squamous metaplasia; DYS, dysplasia. d LINC00930 expression were measured in NPC tissues and their adjacent tissues in cohort 1 (n = 71, wilcoxon test). e Survival was analyzed and compared between patients with low and high levels of LINC00930 in cohort 1 (n = 71, log-rank test, two-sided). LINC, LINC00930; HR, Hazard Ratio. f Multivariable analysis was performed in cohort 1. All the bars correspond to 95% confidence intervals. g Comparing different AJCC stages, positive or negative lymphatic invasion, metastasis, and pathological differentiation between LINC00930 high- and low-expression tumors of cohort 2. The heatmap illustrated the association of different clinical characters with LINC00930 high- and low-expression tumors using ISH analysis in cohort 2 (n = 128, chi-square test). PD, pathological differentiation. h Survival was analyzed and compared between patients with high and low levels of LINC00930 expression in tumor in cohort 2 (n = 128, log-rank test, two-sided). i Multivariable analysis was performed in cohort 2. All the bars correspond to 95% confidence intervals