Table 1.

The schedule of enrollment, interventions, and assessments

Workflow	Enrollment	Allocation	Follow-up					Close-out
	− 7 days	Day 0	Day 1	Day 7	Day 14	Day 30	Day 60	Day 90
Enrollment
Eligibility screening	✓
Informed consent	✓
Allocation		✓
Interventions
FMT capsules			✓	✓	✓
Placebo capsules			✓	✓	✓
Assessments
Comorbid diseases and treatment	✓
Physical examination	✓							✓
Office BP and heart rate	✓			✓	✓	✓	✓	✓
24-h ABPM	✓					✓		✓
Blood routine	✓							✓
Urine routine	✓							✓
Blood chemical test	✓							✓
Urine microalbumin, creatinine	✓							✓
ECG	✓							✓
Arterial stiffness (ABI, PWV)	✓							✓
Diet records			✓	✓	✓	✓	✓	✓
Patient compliance			✓	✓	✓
Adverse events			✓	✓	✓	✓	✓	✓
Combined medications for accompanied diseases			✓	✓	✓	✓	✓	✓
Fecal sample collection	✓			✓	✓	✓	✓	✓
Blood sample collection	✓			✓	✓	✓	✓	✓

Blood biochemical test: ALT alanine aminotransferase, AST aspartate aminotransferase, K potassium, Na sodium, Cl chloride, BUN urea nitrogen, CREA creatinine, UA uric acid, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, GLU fasting blood glucose