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. 2022 Feb 23;20:103. doi: 10.1186/s12967-022-03304-y

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Timeline of events extended from birth at postnatal day 1 (P1) through P45 when animals were anesthetized and midbrains were evaluated by magnetic resonance spectroscopy (MRS). Individual animals were identified and tail genotyping was performed at P5. Animals were assigned to three groups: SynCre⁺Pank1,2 dKO ± BBP-671 and SynCre⁻Pank1^fl/fl,Pank2^fl/fl matched wildtype controls, and were housed with control nursing dams at P14. Animals were maintained on the purified chow diet ± 75 ppm BBP-671 starting at P14 through P45, and weaned at P21. Mice were transferred to the Center for In Vivo Imaging and Therapeutics (CIVIT) at approximately P38 and MRS was performed at approximately P45. Numbers of mice in each group are indicated in parentheses