Skip to main content
. Author manuscript; available in PMC: 2022 Feb 24.
Published in final edited form as: Nat Rev Mol Cell Biol. 2020 May 26;21(8):421–438. doi: 10.1038/s41580-020-0250-z

Fig. 5: Role of the UPR in physiology and diseases.

Fig. 5:

Genetic and pharmacological manipulation of major unfolded protein response (UPR) components has revealed that the UPR pathways play a part in the functions of diverse organs and cell types. Preclinical models have also shown that dysregulation of UPR signalling, mediated by specific UPR components, contributes to a variety of diseases. The figure illustrates the roles of the UPR in organ physiology (blue) or pathological conditions (pink) affecting the same tissues.