Table 1.

MICs of ARM1 and its derivatives against H. pylori standard strain G27 and multidrug‐resistant strain Hp159.

Parent structure	Compound	R1	R2	R3	R4	MIC
						(μg ml‐1)
						G27	Hp159
	ARM1	H	CH3	CH3	Cl	8	8
	2	CH3	H	CH3	Cl	8	4
	3	CH3	CH3	CH3	Cl	8	4
	7	H	CH3	H	Cl	32	16
	8	CH3	H	H	Cl	32	16
	9	CH3	CH3	H	Cl	16	16
	10	H	CH3	H	H	8	8
	11	CH3	H	H	H	16	8
	12	CH3	CH3	H	H	16	16
	13	H	CH3	CH3	H	4	8
	14	CH3	H	CH3	H	4	8
	15	CH3	CH3	CH3	H	4	4
	4	H	CH3	–	–	8	4
	5	CH3	H	–	–	8	8
	6	CH3	CH3	–	–	8	16
	MTZ					2 (S)	16 (R)
	CLR					0.004 (S)	2 (R)
	LVX					0.5 (S)	8 (R)
	AMX					0.125 (S)	0.125 (S)

Breakpoints are according to EUCAST (European Committee on Antimicrobial Susceptibility Testing) guidelines. S, drug sensitive; R, drug resistant; MTZ, metronidazole; CLR, clarithromycin; LVX, levofloxacin; AMX, amoxicillin.