Table 1.
Demographic and clinical data from prospective COVID-19 cohort.
| Demographic | 2nd Trimester COVID (N = 8) | 3rd Trimester COVID (N = 8) | Control (N = 8) | P-Value |
|---|---|---|---|---|
| Gestational age at infection (weeks) – Mean (SD) | 18.7 (4.1) | 30.0 (3.1) | N/A | 2.4e-05 * |
| Duration between infection and delivery (weeks) – Mean (SD) | 21.2 (4.4) | 10.0 (4.2) | N/A | 2.4e-04 * |
| Maternal COVID severity – N (%) | N/A | |||
| Asymptomatic | 0 | 0 | ||
| Mild/moderate symptoms | 8 | 7 | ||
| Hospitalized | 0 | 1 (12.5%) | ||
| ICU | 0 | 0 | ||
| Maternal age (years) – Mean (SD) | 30.0 (5.0) | 30.9 (5.1) | 30.4 (6.6) | 0.95 ** |
| Gravida (number) – Mean (SD) | 3.1 (2.0) | 1.9 (0.8) | 2.7 (1.5) | 0.25 ** |
| Para (number) – Mean (SD) | 1.5 (1.4) | 0.6 (0.7) | 0.6 (0.7) | 0.16 ** |
| Maternal race – N (%) | ||||
| Black | 1 (12.5%) | 1 (12.5%) | 0 | 0.90 |
| White | 3 (37.5%) | 2 (25%) | 2 (25%) | |
| Other | 4 (50%) | 5 (62.5%) | 6 (75%) | |
| Maternal ethnicity – N (%) | 5 (62.5%) | 6 (75%) | 6 (75%) | 1 |
| Hispanic/Latino | ||||
| Maternal chronic health conditionsa – N (%) | 3 (37.5%) | 4 (50%) | 5 (62.5%) | 0.87 |
| Pregnancy complicationsb – N (%) | 7 (87.5%) | 8 (100%) | 5 (62.5%) | 0.27 |
| Delivery by c-section – N (%) | 2 (25%) | 3 (37.5%) | 0 | 0.30 |
| Maternal WBC count at delivery – (cells/mL x 1000) – Median (IQR) | 8.7 [6.2–9.2] | 11.2 [9.4–14.2] | 8.2 [6.2–11.93] | 0.40 *** |
| Gestational age at birth (weeks) – Mean (SD) | 39.9 (1.1) | 40.0 (1.9) | 38.6 (0.9) | 0.09 ** |
| Infant sex – N (%) | ||||
| Male | 5 (62.5%) | 2 (25%) | 3 (37.5%) | 1 |
| Female | 3 (37.5%) | 6 (75%) | 5 (62.5%) | |
| Birth weight (grams) – Mean (SD) | 3453 (327) | 3446 (411) | 3353 (459) | 0.86 ** |
| 5-minute APGAR – median (IQR) | 9 [9–9] | 9 [9–9] | 9 [8.75–9.00] | 0.12 * ** |
| Required NICU admission – N (%) | 1 (12.5%) | 0 | 1 (12.5%) | 1 |
| Infant COVID-19 nasal swab positive results | 0 | 0 | 0 | N/A |
P-values for continuous variables were generated using t-test (indicated by (*), ANOVA test (indicated by ** ), or Kruskal Wallis rank test (indicated by *** ). P-values for categorical variables were generated using the Fisher exact tests.
a
Chronic health conditions included autoimmune disease, diabetes, hepatitis B, hepatitis C, HSV, HIV, hypertension, obesity, thyroid disease, substance use disorder, or other
b
Pregnancy complications included chorioamnionitis, gestational diabetes, hypertensive disorder of pregnancy, fetal growth restriction, placenta previa, preterm labor, unexplained vaginal bleeding, or other