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. 2022 Feb 10;10:813370. doi: 10.3389/fcell.2022.813370

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Copyright © 2022 Li, Wang, Liu, Zhang, Cao, Jiang, Sun, Li, Wang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Protective effects of HAR on DICT zebrafish and mice. (A) Representative images of zebrafish heart and tail blood flow captured by high-speed camera. (B,C) Quantitative analysis of fractional shortening (FS) value of zebrafish hearts and blood flow of zebrafish tail. (D) Assessment of survival rate of zebrafish under different drug treatment. (E) A schematic diagram of animal model generation and drug administration. (F) Body weight changes in various groups (n = 10). (G) Representative images of echocardiograms. (H) Left ventricular ejection fraction and fractional shortening (n = 6). (I) Representative images of morphological and structural changes in the myocardium detected by H&E staining. Scale bar: 20 μm. (J) The content of serum CK-MB and LDH (n = 6). ***p < 0.001 vs. DOX group. #p < 0.05 vs. (DOX + HAR) group. The data are shown as the mean ± s.d.