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. 2022 Feb 10;11:810023. doi: 10.3389/fonc.2021.810023

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Copyright © 2022 Tolaney, Beeram, Beck, Conlin, Dees, Puhalla, Rexer, Burris, Jhaveri, Helsten, Becerra, Kalinsky, Moore, Manuel, Lithio, Price, Chapman, Litchfield and Goetz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Change in Tumor Size for Patients with Measurable Disease. Best percent change in tumor size for 31 patients in Parts A–D with measurable disease and available post-baseline assessments, colored by response according to Response Evaluation Criteria in Solid Tumours v1.1. Change in tumor size greater than 100% is truncated at 100%. Comparison among study parts is not possible due to differences in patient and disease characteristics and because enrollment opened sequentially: Part A-letrozole and Part B- anastrozole → Part C-tamoxifen → Part D-exemestane.