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. 2022 Feb 10;11:810023. doi: 10.3389/fonc.2021.810023

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Copyright © 2022 Tolaney, Beeram, Beck, Conlin, Dees, Puhalla, Rexer, Burris, Jhaveri, Helsten, Becerra, Kalinsky, Moore, Manuel, Lithio, Price, Chapman, Litchfield and Goetz

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mean Plasma Concentrations of Abemaciclib Following Single and Multiple Doses. Mean plasma concentration vs. time profiles of abemaciclib following oral administration of abemaciclib with combination therapies after a single abemaciclib dose (200 mg; (A) and on Cycle 2 Day 1 at steady state after multiple twice daily abemaciclib doses (100 to 200 mg; (B). Plasma concentration data for abemaciclib and metabolites were available from 67 patients (n=20, letrozole; n=16, anastrozole; n=16, tamoxifen; n=15, exemestane). hr, hour.