Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
ERdj3 is a UPR-regulated secreted chaperone. In the absence of ER stress, ERdj3 dimers engage ER-localized SDF2/SDF2L1 to bind misfolded proteins and deliver them to BiP for ATP-dependent chaperoning. Upon ER stress, ERdj3 assembles into a homotetramer that is secreted to the extracellular space, where it can function as an extracellular chaperone. Created with BioRender.com.
