Table 6.
Anti-proliferative activity (HT29), cytotoxicity (Caco-2), and selectivity index of optimal NADES raspberry extract (Opt3), raspberry ethanolic extract (ETOH 80%), and pure acidic NADES (CA:BET:H2O 3:1:3).
| Systems/Compounds | EC50 (mg/mL) | Selectivity Index | |
|---|---|---|---|
| Cytotoxicity (Caco-2) | Anti-proliferative Activity (HT29) | ||
| Opt3—1 a | 3.80 ± 3.33 | 3.18 ± 0.37 | 1.20 |
| Opt3—2 a | ≈4.63 * | 2.16 ± 0.49 | 2.14 |
| Opt3—3 a | 4.60 ± 2.80 | ≈3.84 * | 1.20 |
| ETOH 80%—1 b | 103.10 ± 7.04 | 48.65 ± 11.54 | 2.12 |
| ETOH 80%—2 b | ≈120.60 * | 22.93 ± 4.41 | 5.26 |
| ETOH 80%—3 b | 115.30 ± 12.25 | 61.82 ± 3.17 | 1.87 |
| CA:BET:H2O (3:1:3) | 8.06 ± 4.26 | 2.08 ± 0.14 | 3.88 |
* In the range of concentrations tested, it was impossible to accurately determine the SD of the EC50. Other results are expressed as mean ± sd n = 3; a—All samples were obtained under the same extraction conditions; b—All samples were obtained under the same extraction conditions.