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. 2022 Feb 9;7(7):6046–6052. doi: 10.1021/acsomega.1c06394

Figure 4.

Figure 4

Predictive model of the regulation of TS status by balancing the accumulation of the inactive FdUMP-TS form and the storage of the active free-TS form in the 5-FU-resistant HCT116RF10 cells and parental HCT116 cells. We show that the trapping of FdUMP by TS enzyme is more effective in 5-FU-resistant HCT116RF10 cells than in parental HCT116 cells. In addition, we predict that the regulation of the balance between the storage of the active TS form and the accumulation of FdUMP-TS is responsible for direct resistance to 5-FU. 5-FU, 5-fluorouracil; FUdR, 5-fluorodeoxyuridine; FdUMP, 5-fluorodeoxyuridine monophosphate; TS, thymidylate synthase.