Table 3.
Lymphocyte types and function.
| Lymphocyte Type | Human Markers | Mice Markers | Characteristics | References |
|---|---|---|---|---|
| B1 cells | High levels of IgM | High levels of IgM | Active in innate immunity housed in the peritoneal and pleural cavities | |
| low levels of IgD, detectable levels of CD5 | Low levels of IgD, detectable levels of CD5 | [88,89,90,91] | ||
| B2, follicular B cells (FOB) | CD10, CD19+ CD20, CD21mid, CD22, CD23, CD24low | CD1dlow, CD19mid, CD21mid, CD22, CD23, CD24low, CD38+ | Housed in the spleen and lymph nodes Participate in T-cell-dependent immune responses | |
| B2, marginal zone B cells (MZB) | CD1c, CD19+, CD20, CD21high, CD27+, IgM+ | CD1dhigh, CD19mid, CD21high, CD22, CD23, CD35+, CD43− | Housed in the spleen and lymph nodes Active in early immune response and can uptake ox-LDL | |
| T cells,Th1 | CCR1+, CCR5+, CD3+, CD4+, CD8−, CD14−, CD19−, CXCR3+ | CCR1+, CCR5+, CD3+, CD4+, CD8−, CD14−, CD19−, CXCR3+ | Promote lesion destabilization Alter endothelial function Most abundant type at lesion sites | |
| T cells,Th2 | CCR3+, CCR4+, CCR8+, CD3+ CD4+, CD8−, CD14+, CD19+ | CCR3+, CCR4+, CCR8+, CD3+, CD4+, CD8−, CD14+, CD19+ | Inhibit TH1 differentiation and promote the survival and proliferation of mast cells |