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. 2022 Jan 18;11(2):126. doi: 10.3390/antibiotics11020126

Figure 1.

Figure 1

Model of MexA–MexB–OprM tripartite complex and position of Q93 residue in α-hairpin of MexA. (A) Model representation of OprM–MexA–MexB tripartite complex (PDB: 6TA5) showing OprM (OMF component) trimer (colored in orange) and MexB (RND component) trimer (colored in blue) connected by MexA (PAP component) hexamer (colored in green). The outer membrane (OM) and inner membrane (IM) are schematically drawn (black dashed lines). The position of the residue Q93 is shown in red (side chain). The position of V472 (or V455 in mature OprM sequence numbering) corresponding to the C-terminal residue solved in OprM structure is indicated on two protomers in the equatorial domain (black arrows). Residues T473–A485 are not visible in the structure. (B) Close-up view of the position of the Q93 residue relative to the tip-to-tip contact between OprM and MexA.