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. 2022 Jan 18;11(2):126. doi: 10.3390/antibiotics11020126

Figure 6.

Figure 6

Hypothetic model of PAP interprotomer stabilization mediated by paired anionic-cationic residues in the tip-to-tip PAP–OprM contact. (A) Focus on OprM–MexA contact from cryo-EM model of OprM–MexA–MexB (PDB: 6TA5). Positions of residues Q93 and D113 are shown on MexA (colored in green). OprM is colored in orange. (B) Model of MexAQ93R (light green) interacting with OprM (orange). Distance between R93 and D113 (2.96 Å) is compatible with interprotomer electrostatic interactions. (C) Model of MexX (blue) interacting with OprM with putative interprotomer interactions mediated by side chains of K102–E122 residues. (D) Model of MexE (purple) interacting with OprM with putative interprotomer interactions mediated by R97–E128 side chains.