Table 1.

The History of curcumin.

Year	Discovery	Reference
1815	Vogel and Pelletier were the first to report the “Orange-yellow Substance” isolated from the rhizome of Curcuma longa and named it curcumin.	[16]
1842	Vogel Extracted pure preparation of curcumin but did not report its formula.	[17]
1910	Milobedzka and Lampe identified chemical structure of curcumin as diferuloylmethane, or 1,6-heptadiene-3,5-dione-1,7-bis-(4-hidroxy-3-methoxyphenyl)-(1E, 6E).	[18]
1913	The synthesis of curcumin was published.	[19]
1949	Schraufstatter et al. Reported that curcumin is a biologically active compound with antibacterial properties.	[20]
1953	Srinivasan separated and quantified the components of curcumin using chromatography.	[21]
1971	It was discovered that curcumin lowers cholesterol	[22]
1972	It was discovered that curcumin lowers the level of sugar in the blood	[23]
1973	It was discovered that curcumin has an anti-inflammatory effect	[24]
1976	It was discovered that curcumin has an antioxidant effect	[25]
1980	Kuttan et al. demonstrated anticancer activity of curcumin both in vitro and in vivo.	[26]
1995	Curcumin exhibits anti-inflammatory activity by suppressing the proinflammatory transcription factor, nuclear factor-kappa B (NF-κB)	[27]