. 2022 Feb 16;11(2):258. doi: 10.3390/antibiotics11020258

Table 1.

Summary of genes associated with elevated vancomycin MICs.

Ref.	No. Isolates ^†	Strain Origin	Ribotype	ST Type	Other	Gene (Mutation, If Known)							VAN MIC (mg/L)
Ref.	No. Isolates ^†	Strain Origin	Ribotype	ST Type	Other	vanG/vanSR	vanA	vanB	vanW	vanZ	murG	rpoC	VAN MIC (mg/L)
[22]	4	Clinical	012	54	NAP_CR1	vanG							4
[23] *	1	Laboratory	027	1	WS2/ R20291	vanS (Arg314Leu)							8
	1	Laboratory	027	1	WS4/ R20291	vanS (Gly319Asp)							16
	1	Clinical	027	1	MT1470	vanS (Ser313Phe)							8
	1	Clinical	027	1	MT5006	vanS (Thr349Ile)							8
	9	Clinical	027	1	see note ^‡	vanR (Thr115Ala)							4–8 ^‡
[24]	1	Clinical		35			vanA		vanW				4
	1	Clinical	014-020	2				vanB					8
	1	Clinical		42				vanB					4
	1	Clinical		67				vanB	vanW				>16
	1	Clinical	012	54					vanW	vanZ			4
[25] *	1	Laboratory	087		NB95013/ATCC 43255						murG/cd2725 (Pro108Leu)		16
[25] *	1	Laboratory			NB95026							rpoC/cd0067 (Gly733Thr)	16

Abbv: Ref., reference; no., number; ST, multilocus sequence type; MIC, minimum inhibitory concentration; VAN, vancomycin. Notes:* These studies utilized serial passaging and selection for mutants with decreased susceptibility. † Number of isolates expressing resistance, defined as vancomycin MIC > 2 mg/L [4,5]. ‡ 7 isolates from the Texas Medical Center had MICs = 4 mg/L and 2 isolates from Israel had MICs = 8 mg/L