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. 2022 Feb 4;11(2):314. doi: 10.3390/antiox11020314

Figure 4.

Figure 4

Epac1 regulates mitochondria function in neuronal HT-22 cells. (A) Schematic of oxygen consumption rate (OCR) of HT-22 cells during the Seahorse Assay (Normalized OCR). (B) Basal respiration of HT-22 cells before injections of the Seahorse Assay. (C) ATP-linked respiration of HT-22 cells. (D) Maximum oxygen consumption rate, of maximal respiration of HT-22 cells. (E) Maximal respiration of HT22 cells on stimulation with 100 μM CE3F4 alone. Control is DMSO 1% and erastin 1 μM is used for the experiments. n = at least 3 biological replicates with n = 6 technical replicates for each biological replicate. * Comparison of the group against control, # comparison between different treatment groups, as indicated. One-Way ANOVA statistical analysis with Bonferroni correction was used. ns p > 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001. #### p < 0.0001.