Table 1.
List of the new β-lactam β-lactamase inhibitors against target carbapenem-resistant Gram-negative bacteria.
| New BLBLIs | CPE-KPC | CPE-MBLs | CPE-OXA-48 | CRPA (Non-MBL-Producing) |
CRAB |
|---|---|---|---|---|---|
| Ceftazidime-avibactam | + | − | + | + | − |
| Imipenem-cilastatin-relebactam | + | − | − | + | − |
| Meropenem-vaborbactam | + | − | − | − | − |
| Ceftolozane-tazobactam | − | − | − | + | − |
| Aztreonam-avibactam | + | + | + | − | − |
| Cefepime-zidebactam | + | + | + | + | − |
| Cefepime-taniborbactam | + | +/− | + | + | − |
| Sulbactam-durlobactam | − | − | − | − | + |
+, active; −, not active; Abbreviations: BLBLIs, β-lactam β-lactamase inhibitors; CPE, carbapenemase-producing Enterobacterales; KPC, Klebsiella pneumoniae carbapenemase; MBLs, metallo- β-lactamases; OXA-48, oxacillinase-48; CRPA, carbapenem-resistant Pseudomonas aeruginosa; CRAB, carbapenem-resistant Acinetobacter baumannii.