Skip to main content
. 2022 Jan 25;11(2):153. doi: 10.3390/antibiotics11020153

Table 3.

Synergy outcomes of fosfomycin-meropenem combination using the Checkerboard assay in K. pneumoniae isolates.

Fosfomycin MIC (mg/L) Meropenem MIC (mg/L)
Isolate Genotype
/MLST
Alone Combined Fold Decline Alone Combined Fold Decline FICI (x)
Kp1 OXA-232/ST-231 128 16 8 8 1 8 0.25
Kp2 OXA-232/ST-231 32 4 8 16 4 4 0.37
Kp3 ST-231
OXA-232
64 16 4 16 4 4 0.50
Kp4 ST-231 NDM-1 64 8 8 64 2 32 0.16
Kp5 OXA-232/ST-231 64 8 8 16 4 4 0.37
Kp6 OXA-232/ST-231 64 8 8 8 2 4 0.37
Kp7 OXA-232/ST-231 64 8 8 16 2 8 0.25
Kp8 OXA-232/ST-231 64 8 8 16 2 8 0.25
Kp9 OXA-232/ST-231 64 16 4 16 4 4 0.50
Kp10 OXA-232/ST-231 64 16 4 8 1 8 0.37
Kp11 ST-231 NDM-1 64 8 8 128 16 8 0.25
Kp12 OXA-232/ST-231 64 16 4 8 2 4 0.50
Kp13 OXA-232/ST-395 64 8 8 16 1 16 0.19
Kp15 OXA-232/
ST-231
64 8 8 8 2 4 0.37
Kp16 OXA-232+
NDM-5/ST147
64 16 4 128 32 4 0.50
Kp17 OXA-232/ST-231 64 8 8 128 32 4 0.37
Kp18 OXA-232/ST-395 64 8 8 8 2 4 0.37

Abbreviation: Kp = K. pneumoniae, FICI = fractional inhibition concentration index, x = mean value.