Table 3.
Fosfomycin MIC (mg/L) | Meropenem MIC (mg/L) | |||||||
---|---|---|---|---|---|---|---|---|
Isolate | Genotype /MLST |
Alone | Combined | Fold Decline | Alone | Combined | Fold Decline | FICI (x−) |
Kp1 | OXA-232/ST-231 | 128 | 16 | 8 | 8 | 1 | 8 | 0.25 |
Kp2 | OXA-232/ST-231 | 32 | 4 | 8 | 16 | 4 | 4 | 0.37 |
Kp3 | ST-231 OXA-232 |
64 | 16 | 4 | 16 | 4 | 4 | 0.50 |
Kp4 | ST-231 NDM-1 | 64 | 8 | 8 | 64 | 2 | 32 | 0.16 |
Kp5 | OXA-232/ST-231 | 64 | 8 | 8 | 16 | 4 | 4 | 0.37 |
Kp6 | OXA-232/ST-231 | 64 | 8 | 8 | 8 | 2 | 4 | 0.37 |
Kp7 | OXA-232/ST-231 | 64 | 8 | 8 | 16 | 2 | 8 | 0.25 |
Kp8 | OXA-232/ST-231 | 64 | 8 | 8 | 16 | 2 | 8 | 0.25 |
Kp9 | OXA-232/ST-231 | 64 | 16 | 4 | 16 | 4 | 4 | 0.50 |
Kp10 | OXA-232/ST-231 | 64 | 16 | 4 | 8 | 1 | 8 | 0.37 |
Kp11 | ST-231 NDM-1 | 64 | 8 | 8 | 128 | 16 | 8 | 0.25 |
Kp12 | OXA-232/ST-231 | 64 | 16 | 4 | 8 | 2 | 4 | 0.50 |
Kp13 | OXA-232/ST-395 | 64 | 8 | 8 | 16 | 1 | 16 | 0.19 |
Kp15 | OXA-232/ ST-231 |
64 | 8 | 8 | 8 | 2 | 4 | 0.37 |
Kp16 | OXA-232+ NDM-5/ST147 |
64 | 16 | 4 | 128 | 32 | 4 | 0.50 |
Kp17 | OXA-232/ST-231 | 64 | 8 | 8 | 128 | 32 | 4 | 0.37 |
Kp18 | OXA-232/ST-395 | 64 | 8 | 8 | 8 | 2 | 4 | 0.37 |
Abbreviation: Kp = K. pneumoniae, FICI = fractional inhibition concentration index, x− = mean value.