Table 2.
Subject demographic and baseline characteristics.
| Demographic Data | Baseline | 2 g CAW * | 4 g CAW * |
|---|---|---|---|
| Gender, % (n) | |||
| Female | 40% (n = 2) | 25% (n = 1) | 25% (n = 1) |
| Male | 60% (n = 3) | 75% (n = 3) | 75% (n = 3) |
| Age a (year) | 70 [59] | 67.8 [2.8] | 67.8 [2.8] |
| Body mass index b (kg/m2) | 28 ± 2 | 27 ± 2 | 27 ± 2 |
| Systolic blood pressure b (mmHg) | 132 ± 7 | 117 ± 5 | 124 ± 5 |
| Diastolic blood pressure b (mmHg) | 81 ± 3 | 75 ± 3 | 74 ± 3 |
| Body temperature b (°C) | 36.7 ± 0.08 | 36.6 ± 0.03 | 36.9 ± 0.08 |
| Heart rate b (bpm) | 68 ± 5 | 69 ± 3 | 62 ± 5 |
| Race, % (n) | |||
| American Indian/Alaska Native | 0 | 0 | 0 |
| Asian | 0 | 0 | 0 |
| Black or African American | 0 | 0 | 0 |
| Native Hawaiian or Other Pacific Islander | 0 | 0 | 0 |
| White | 100 (5) | 100 (4) | 100 (4) |
| Clinical laboratory screening b | |||
| White blood cell (×103/µL) | 7.28 ± 0.60 | NM | NM |
| Red blood cell (×106/µL) | 4.64 ± 0.21 | NM | NM |
| Hemoglobin (g/dL) | 14.3 ± 0.6 | NM | NM |
| Hematocrit (%) | 44 ± 2 | NM | NM |
| Platelet (×103/µL) | 259 ± 20 | NM | NM |
| Blood glucose (mg/dL) | 81 ± 3 | 92 ± 6 | 89 ± 8 |
| Blood urea nitrogen (mg/dL) | 17 ± 3 | 24 ± 2 ^ | 24 ± 3 ^ |
| Creatinine (mg/dL) | 0.90 ± 0.06 | 0.85 ± 0.06 | 0.83 ± 0.09 |
| Total bilirubin (mg/dL) | 0.6 ± 0.1 | 0.7 ± 0.1 | 0.8 ± 0.1 |
| Aspartate aminotransferase (U/L) | 26 ± 3 | 28 ± 6 | 37 ± 2 |
| Alanine aminotransferase (U/L) | 32 ± 3 | 39 ± 6 | 43 ± 7 |
| Alkaline phosphatase (U/L) | 87 ± 12 | 84 ± 9 | 80 ± 7 |
| Total Protein (g/dL) | 7.7 ± 0.1 | 7.2 ± 0.2 | 7.1 ± 0.2 |
| Albumin (g/dL) | 3.8 ± 0.1 | 3.7 ± 0.1 | 3.6 ± 0.1 |
| Sodium (mmol/L) | 141 ± 1 | 141 ± 1 | 141 ± 1 |
| Chloride (mmol/L) | 108 ± 1 | 109 ± 0.5^ | 110 ± 1 ^ |
| Potassium (mmol/L) | 3.8 ± 0.1 | 3.8 ± 0.2 | 4.1 ± 0.3 |
| Total CO2 (mmol/L) | 29 ± 1 | 28 ± 0.3 | 28 ± 1 |
| Calcium (mg/dL) | 9.3 ± 0.1 | 9.1 ± 0.1 | 9.3 ± 0.9 |
| Anion Gap | 5 ± 1 | 5 ± 1 | 4 ± 1 |
a Data are expressed as median [IQR]. b Data are expressed as mean ± SEM, (n = 5 for baseline, n = 4 for 2 g CAW and 4 g CAW). ^ = outside of reference range but deemed not clinically significant. NM = Not measured. * = Data from 10 h time point.