Table 5.
Oxidative, inflammatory, and apoptotic/anti-apoptotic levels related to mortality.
| Laboratory Assay | Survival | Mortality | p # |
|---|---|---|---|
| TOS/TAC ratio, median (IQR) | 1.52 (0.7–3) | 7.5 (3.2–26) | 0.001 |
| TOS, median (IQR) | 318 (172.5–568) | 1243 (505–2104) | 0.001 |
| TAC, median (IQR) | 197 (160–257) | 142 (72–258) | 0.001 |
| IL-6 (pg/mL), median (IQR) | 32 (3.7–130) | 64 (26–310) | 0.002 |
| IL-8 (pg/mL), median (IQR) | 60.6 (30–168) | 77.8 (51.4–126) | 0.785 |
| IL-10 (pg/mL), median (IQR) | 9 (1.2–20) | 13.9 (1.5–55) | 0.148 |
| IL-27 (pg/mL), median (IQR) | 0.4 (0.2–0.7) | 0.6 (0.26–0.95) | 0.015 |
| Hsp72 (ng/mL), median (IQR) | 0.27 (0.14–0.70) | 0.58 (0.24–1.5) | 0.001 |
| Hsp90 (ng/mL), median (IQR) | 54.8 (25.4–117) | 62.4 (35–146) | 0.105 |
| IFN-γ (IU/mL), median (IQR) | 5.1 (0.6–10.3) | 6.69 (3.15–13.3) | 0.196 |
| TNF (pg/mL), median (IQR) | 7.85 (3. 6–67.7) | 4.62 (4.4–4.8) | 0.543 |
| Zinc (μg/dL), median (IQR) | 56 (41–76) | 55.5 (43–66) | 0.409 |
| Survivin-WT isoform (copies/μL), median (IQR) | 0.007 (0.002–0.03) | 0.022 (0.004–0.27) | 0.019 |
| Survivin-2B isoform (copies/μL), median (IQR) | 0.13 (0.01–0.3) | 0.16 (0.04–0.35) | 0.015 |
| Survivin protein (pg/mL), median (IQR) | 136.7 (84–240) | 179 (130–424) | 0.002 |
| Caspase-3 (ng/mL), median (IQR) | 21.1 (4.5–55.4) | 15.2 (5.1–92.6) | 0.674 |
| Caspase-9 (ng/mL), median (IQR) | 102 (87.5–136.5) | 99 (90.3–123.4) | 0.784 |
# Differences among groups (Mann–Whitney U-test): TOS = Total Oxidative Stress, TAC = Total antioxidant capacity, IQR = Interquartile Range, TNF = tumor necrosis factor, Hsp = heat shock protein, IL = interleukins, IFN-γ = interferon gamma, TNF = tumor necrosis factor.