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. 2022 Feb 10;11(2):349. doi: 10.3390/antiox11020349

Figure 5.

Figure 5

Effects of Na2SeO3 and L-SeMC on the Keap1/Nrf2 pathway in PA-induced AML-12 cells. (A) The mRNA level of Sepp1 (n = 3, ** p < 0.01, * p < 0.05). (B) The protein level of SEPP1 (n = 3, ** p < 0.01, * p < 0.05). (C) The total protein level of NRF2 (n = 3, * p < 0.05). (D) The accumulation of NRF2 in the nucleus was detected by immunofluorescence (400× magnification). (E) The nuclear protein level of NRF2 (n = 3, *** p < 0.001, ** p < 0.01, * p < 0.05). (F) The protein level of GPX1 (n = 3, *** p < 0.001, ** p < 0.01). (G) The enzyme activity of GPX1 (n = 3, ** p < 0.01, *p < 0.05).