Table 2.
MIC and FIC index of octyl gallate (OG) and β-lactam combinations against MRSA isolates from clinical cases in humans.
| Strain | MIC (μg/mL) | MIC of Combinations (μg/mL) ⱡ | FIC Index | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PEN | AMP | CEP | PEN + OG | AMP + OG | CEP + OG | PEN + OG | AMP + OG | CEP + OG | |
| MRSA 3795 | >64 | >64 | >64 | 0.063 (>1024) | 0.125 (>512) | 1 (>64) | 0.032 | 0.032 | 0.039 |
| MRSA 3823 | >64 | >64 | >64 | 0.063 (>1024) | 0.125 (>512) | 1 (>64) | 0.126 | 0.126 | 0.133 |
| MRSA 3865 | 64 | >64 | >64 | 0.5 (128) | 1 (>64) | 4 (>16) | 0.070 | 0.070 | 0.156 |
| MRSA 3903 | >64 | >64 | >64 | 0.125 (>512) | 0.125 (>512) | 1 (>64) | 0.126 | 0.126 | 0.133 |
PEN: penicillin, AMP: ampicillin, CEP: cephalothin, OG: octyl gallate. ⱡ: Fold changes in the MICs and MICs of antibiotics and 4 μg/mL OG combinations in comparison with those of antibiotics alone are indicated in parentheses.