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. 2022 Jan 20;11(2):198. doi: 10.3390/antiox11020198

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Volcano plot analysis of TBHP-induced, iPLA₂γ-dependent cleavage of phospholipids. Brain mitochondria isolated from WT mice and respiring in the presence of TBHP are related to mitochondria with no treatment frozen immediately after isolation (A) and to mitochondria treated with TBHP + r-BEL (C). Analogously, brain mitochondria isolated from iPLA₂γ-KO mice and respiring in the presence of TBHP are related to mitochondria with no treatment frozen immediately after isolation (B) and to mitochondria treated with TBHP + r-BEL (D). TBHP + CATR treatment is related to mitochondria with no treatment frozen immediately after isolation in WT (E) and iPLA₂γ-KO (F) mice. Abbreviations: SFAs, saturated FAs; MFAs, monoenoic FAs; PUFA, polyunsaturated FAs; MLCL, monolysocardiolipin; DLCL, dilysocardiolipin; CL, cardiolipin; LPC, lysophosphatidylcholine; LPE, lysophosphatidylethanolamine; LPG, lysophosphatidylglycerol; LPI, lysophosphatidylinositol; LPS, lysophosphatidylserine. Lipidomics data were collected from n = 6 replicates.