Figure 10.

The putative roles of iPLA₂γ in post-biosynthetic cardiolipin remodeling and degradation. Shown are steps from newly synthesized nascent cardiolipin (CL) to mature CL. The iPLA₂γ-catalyzed deacylation of CL yields fatty acid (depicted as squiggle) and monolysoCL (MLCL) and is followed by reacylation catalyzed by either (1) Tafazzin transacylase (TAFF) or by (2) MLCL acyltransferase (MLCL-AT). Abbreviations: PG, phosphatidylglycerol; CLS, CL synthase; DAG, diacylglycerol; CDP, cytidine diphosphate; CMP, cytidine monophosphate; SFA, saturated fatty acid; MFA, monoenoic fatty acid; PUFA, polyunsaturated fatty acid; PE, phosphatidylethanolamine; PC, phosphatidylcholine; DLCL, dilysoCL.