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. 2022 Jan 29;11(2):275. doi: 10.3390/antiox11020275

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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IGFBP6 modulates mitochondrial metabolism and promotes breast cancer cell proliferation. Evaluation of relative mRNA expression levels of PGC1 alpha, SIRT1, COX IV, COX II and ATPsyn (A), following 24 h of IGFBP6 (400 ng/mL) treatment. The calculated value of 2^-ΔΔCt in untreated controls is 1. Effect of IGFBP6 exposure (800 ng/mL) on cell proliferation (B), colony formation capacity (C) and wound healing (D). Data are expressed as mean ± SD of at least four independent experiments. **** p < 0.0001.