Table 5.

Redox-signalling pathway-induced inflammasome activation in CKD.

CKD Model	Redox-Signalling-Induced Inflammasome Activation	Effects	Reference
IgA-induced nephropathy	NF-κB/NLRP3	The activation of NF-κB induces NLRP3 activation, required for progression promoted by IgA	[244]
IgA-induced nephropathy	decreasedNrf2/NLPR3	IgA deactivates Nrf2, increasing ROS and oxidative stress, inducing NLRP3 activation	[243]
DOCA/salt-induced hypertension	NOXs/ROS/NLRP3	The decreasing of ELABELA activates the NOXs/ROS/NLRP3 pathway	[242]
Ang II-induced DN	Ang II/ROS/NF-κB/NLRP3	Ang II induces proliferation and the biomarker expressions FN, Col IV and CTGF, inducing fibrosis.	[241]

IgA: immunoglobulin A; DOCA: deoxycorticosterone acetate; NOXs: NADPH oxidases; STZ: streptozotocin; Nrf2: nuclear factor erythroid 2-related factor 2; NF-κB: nuclear factor-κB; NLRP3: nucleotide-binding and oligomerization domain-like receptor family pyrin domain-containing 3; Ang II: angiotensin II.