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. 2022 Jan 28;11(2):263. doi: 10.3390/antiox11020263

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Chondrocyte proliferation is Nrf2- and Keap1-RNAi dependent but methysticin independent. Cell proliferation (a) and metabolic activity (b) of C28/I2 chondrocytes after RNA interference with Nrf2- and Keap1-specific shRNAs were compared with NTC at indicated time points post seeding (in hours). Results are expressed relative to NTC at 0 h (means ± SEM) (n = 4). Methysticin (100 μM) does not significantly affect cell proliferation (c). Results were normalized to the condition without methysticin treatment (n = 9). ***, p < 0.0001; *, p < 0.05; ns, not significant.

Chondrocyte proliferation is Nrf2- and Keap1-RNAi dependent but methysticin independent. Cell proliferation (a) and metabolic activity (b) of C28/I2 chondrocytes after RNA interference with Nrf2- and Keap1-specific shRNAs were compared with NTC at indicated time points post seeding (in hours). Results are expressed relative to NTC at 0 h (means ± SEM) (n = 4). Methysticin (100 μM) does not significantly affect cell proliferation (c). Results were normalized to the condition without methysticin treatment (n = 9). ***, p < 0.0001; *, p < 0.05; ns, not significant.